ZR Screen (with FG_2026) — LNP Delivery Screen

Viability

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Rank	Lipid	Percentile	Std	Mean − Std	Viability	Consensus	Cluster

Slot	Group	Name	n	Avg rank	Std rank	Avg score	Std score	Viability	% top 10%

– percentile

Rank

Std (folds)

Viability

Consensus

Formula

Structure

Rendering structure…

SMILES

Composition rank within slot

Starter

Head AA1

Head AA2

Head AA3

Linker AA1

Linker AA2 (fixed)

Linker AA3

Tail

Structural features

Tails

Carbons / tail

C=C bonds

Protonatable groups

Formal charge

Mol. weightg/mol

Heavy atoms

Physicochemical

cLogP

TPSAÅ²

H-bond donors

H-bond acceptors

Rotatable bonds

Per-fold percentile delivery

Toxicity predicted cell viability · higher = safer

Mean viability

Std (folds)

Mean percentile

Std percentile

Per-fold viability

Per-fold percentile

Screening condition held constant

Helper lipid

Cell line

Molar ratio

Cargo

Lipid : nucleic acid

Dose