LNP Delivery Screen

Viability

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Rank	Lipid	Percentile	Std	Mean − Std	Viability	Tails	Cluster

Rank	Condensed lipid	Percentile	Max − Std	Viability	Variants	Tails	Cluster

Class	Group	Name	n	Avg rank	Std rank	Avg score	Std score	Viability	% top 10%

– percentile

Rank

Std (folds)

Viability

Formula

Structure

Rendering structure…

SMILES

Composition rank within group type

Starter

Head

Linker

Tail

Structural features

Tails

Carbons / tail

C=C bonds

Protonatable N

Mol. weightg/mol

Per-fold percentile delivery

Toxicity predicted cell viability · higher = safer

Mean viability

Std (folds)

Mean percentile

Std percentile

Per-fold viability

Per-fold percentile

Screening condition held constant

Helper lipid

Cell line

Molar ratio

Cargo

Lipid : nucleic acid

Dose